Pregnancy has many effects on the body
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As anyone who experiences it, he knows that pregnancy largely changes the body – and now we have the most detailed picture how it affects blood, organs and immune systems on a weekly basis. This can help provide treatment after pregnant, as well as reveal the risks of developing certain conditions when pregnant.
“We found an unprecedented scene in the way that the mother’s body is changing the week -head -wealth, to compensate for the incredible load on it, and how much time does it take to recover after delivery,” Uri alone At the Veizman Institute of Science at Rehovot, Israel.
Despite its importance, pregnancy is understood, says Alon. For example, previous research has tracked how about 20 blood markers, such as salt and iron levels, changes About 6 weeks in dozens of women during pregnancy After delivery, using samples taken during standard healthcare. “These experiments are usually performed on a small number of patients, and they take a sample of every quarter or once after delivery,” Alon says.
To get a more comprehensive approach, Alon and his colleagues first analyzed blood samples collected from more than 160,000 women in Israel, which were 25 to 31 years old, collectively conceived over 300,000. Together, these samples provided a snapshot of the body every week 20 weeks before the conception 18 months before the delivery, each woman provided data for some points in time. This approach gives a useful insights how the body usually changes during pregnancy at a population level, although tracking the same women over time will find a better picture of personal trajectory, says Christof lees At Imperial College London.
Researchers changed 76 blood markers, such as protein, fat and salts levels, which indicate the function of liver, kidneys, blood, muscles, bones and immune systems. They found that each of these markers differ widely from the level of pre-proclamation during pregnancy, either gradually overshoots before returning to pre-generous levels or before settling back to the pre-governance base.
In particular, scientists found that 36 out of 36 markers related to blood clotting, jumped back within a month after delivery, 31 markers took more than 10 weeks to recover. For example, some changes in the liver and immune system took about 5 months to return to pre -pregnancy levels, and many kidney markers took about half a year. Some bone and muscle markers took even longer. What it really means for women’s health is not clear, but it should be detected in future work, says alone.
What is more, some other markers even after one year of birth, never returned to baseline levels. “Slightly old -fashioned scene that six or eight weeks after pregnancy, everyone is completely normal, clearly incorrect,” says the lease.
For example, the iron level was low after giving birth. “Women are likely to be anemic (iron levels are low) after delivery due to hemorrhage, and because a developing fetus takes a lot of iron shops from their body,” laces. “We usually think that it takes six to 12 months for iron shops to be normal – it shows that it may take even more time.”
Meanwhile, a protein level called CRP was high. “CRP is influenced by many different processes, definitely inflammation is one of them, but things such as hormonal changes can also affect it,” is called leis. In another analysis, the team saw the difference in markers among women who had pre-eclampsia-a condition during the pregnancy where high blood pressure headaches, vision problems and pain under the ribs could cause pain-and those who were not. This showed that, before conception, women who developed pre-eclampsia elevated the level of blood cell pieces, called platelets and a protein, called alt.
“For decades, the idea is that the placenta does not transplant properly, and if it does not properly transplant, the blood supply is interrupted, it releases hormones and substances that motivates the mother to receive hypertension,” laces say. “But some studies suggest that people who develop it perform a different heart function before pregnancy – these conclusions add weight to this principle.”
If further studies suggest that these pre-inflammatory markers actually indicate the risk of pre-eclampsia, they may be used to potentially high risk to indicate women at high risk. “Then you can target them with methods of improving health before pregnancy – either through exercise and lifestyle advice – to reduce your risk,” the lease.
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