A species of Penibasillus Bacteria have powerful antibacterial activity against some pathogenic bacteria such as Escherichia coli,Credit: Clouds Hill Imaging Limited/Science Photo Library
Researchers have discovered a new antibiotic molecule that targets a wide range of disease-causing bacteria-even stress resistant to commercial drugs-and not toxic to human cells1,
The molecule was found in soil samples collected from the garden of a laboratory technician. The discovery suggests that Boston, a microbiologist at Northeastar University at Boston, Massachusetts, says, “The terriblely interesting stuff is hidden in plain vision”, who was not involved in research. “Kudos knew them what to see.”
The latest molecule causes the protein -making factory of bacteria, targets ribosomes in a way, which does not perform other antibiotics. Ribosomes are an attractive antibiotic goal because bacteria do not easily develop resistance to drugs that target the structure, calling Lewis.
The discovery of new antibiotics is essential as bacteria receive resistance to existing drugs with continuous use. In 2021, bacterial resistance to antimicrobial drugs was globally associated with 1.1 million deaths, a figure that could increase by 1.9 million by 2050.
“Antibiotic-resistance crisis is an existential threat to the drug,” called a chemical biologist at McMaster University in Hamilton, Macmaster, and a co-writer of the study, a co-writer, Gerry Right, which has been published. Nature Today.
Garden-regional bacteria
Wright and their colleagues have determined to find germs that develop unknown tricks to kill pathogens. They collected soil samples in Petri recipes with development medium and stored them for one year. Researchers then exposed germs with these samples Escherichia coliA normal intestine bacterium that can cause serious illness.
A sample showed powerful antibacterial activity – by a species related to genus Penibasillus,
Further rounds of screening, genome sequencing and structural analysis showed that the bacterium produces a molecule that belongs to a group of peptides that form a laso -shaped knot. These peptides are known to be strong and may also avoid digestion. “This is a good, actually compact and incredibly strong structure,” says Wright.
The molecule, which the researchers named Lariocidin, bind the ribosome and also to move the RNA, which supplies the ribosomes with amino-acid building blocks, requiring the peptide chain to string the peptide chain simultaneously. By doing this, it prevents the genetic code from reading correctly, and also corruption the code while jambing the output. Ultimately, this means that the ribosome produces incorrect peptides, some of which are probably toxic to the bacteria and kill it, called Lewis. And because Lariocidin uses a separate mode of action for other antibiotics, pathogens have already not developed its resistance, he says.
