Filamental fungi is often found in the human intestine.Credit: Dennis Kunkel Microscopy/Science Photo Library
A normal intestinal fungus produces a molecule that reduces the symptoms of non-alcohol fatty liver disease in mice, according to research, according to published research Science Today1,
A step forward to improve treatment for the study disease, which affects about 30% of adults worldwide. Only one drug for the condition is approved by the American Food and Drug Administration, and its limited effectiveness.
Prior to this study, the role of the fungus is called Fusium FotanceIts interaction was poorly understood in human microbiom and with metabolism. Jiang Changto, a microbiologist co-writer at the Peking University Third Hospital in Beijing, says, “We had little understanding of how this fungi developed to collect the intestines of healthy individuals.” Previous studies have shown that the intestine yeast – a type of fungus – can increase the drug addiction liver disease2But what is filamentus fungi F. Fotance The liver situation could affect the condition was not clear.
Changto and his colleagues cultured F. Fotance Using a separation and enrichment system that he designed from human feces. He gave the fungus to the fungi with a type of fatty liver disease, which is called steethaepatitis (MASH) associated with metabolic dysfunction and found that it clearly improves MASH symptoms, such as already existing liver inflammation and reducing liver stains from the disease.
Final reason
Researchers then investigated how the metabolism of treated mice changed. They found that the effect was due to slow synthesis of fatty molecules called Seramides. Ceramides are important for interaction between the intestine and the liver, but are found on a high level with mash in humans and mice.
Researchers cut molecules F. Fotance The fungus is the development medium of culture and found that secretion disrupts ceramide synthesis alone. The team closely analyzed the medium of development and found a molecule that aworide-semide-sinethesizing proteins called Cers6.
The molecule was already found in many fungal species, but its effect on the mash was unknown. Now, there are plans to further analyze the molecules produced by Changto and his team. F, Foytance “To provide a new and effective approach to clinical treatment of mash”.
