Amid the dangerous trend of growing among young people in colorectal cancer cases, a new study has indicated a possible source.
Researchers at San Diego at the University of California have added a bacterial toxin called Colibactin to increase the cases of early-evil.
According to the researchers, colibactin is produced by some strains of Eschherichia coli (E. coli), which are present in the colon and rectum.
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During childhood, in contact with bacterial toxin, the DNA of colon cells can change in a way that increases the risk of development of colorectal cancer before the age of 50, found in the study.
In the study, researchers analyzed 981 colorectal cancer genomes from patients with early start and late colorectal cancer in 11 countries. (Istock)
The study funded by Cancer Research UK was published on 23 April in Journal Nature.
“The major takeaay is that colorectal cancer is a major contribution to the start of collaibactin,” senior writer Ludmil Alexandrov, Shoe Chion-Gain-Gone Plazed Department of Bioinizing and Professor of Cellular and Molecular Medical Department in UC San Diego described Fox News Digital.
“They may be decades before the schedule for the development of colorectal cancer.”
In the study, researchers analyzed 981 colorectal cancer genomes from patients with early start and late colorectal cancer in 11 countries.
Those who had prior contact for colibecin were found specific mutation in their DNA, which is mainly shown in the first decade of life – “Put children on a quick path to develop cancer as young adults.”
During childhood, in contact with bacterial toxin, the DNA of colon cells can change in a way that increases the risk of development of colorectal cancer before the age of 50, found in the study. (Istock)
The group was 3.3 times the beginning of the early colorectal cancer, compared to those diagnosed after 70.
This mutation was found to be 15% of the early genetic changes that increase the risk of colorectal cancer.
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Alexandrov said, “We discovered the mutual signature of colibactin in more than 50% of patients under 40 patients, which, which is less than 10% in the tumor to older, said” Alexandrov said.
Alexandrov said, “If someone receives one of these driver mutations by the age of 10, they can be decades before the schedule for the development of colorectal cancer, can get it at 40 years of age instead of 60,” Alexandrov said.
The fact that a microbial exposure over the first few years of life can leave a “permanent genomic impression” and the possibility can contribute to cancer in adulthood, both “remarkable and cool” according to the researcher.
He said, “It is a reminder that there are many other exposure that we have not yet exposed, and the way we nurture and protect children during these formal years can be long -term implications for their lifetime health,” he told Fox News Digital.
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“From my perspective, investing in the prevention of early life, healthy life and research is not only important-this is necessary.”
Dr. Emil Lu, MD, PhD, a board-prohibited oncologist and internal medical physician at the University of Minnesota agrees that microbiome-“Gyrobiom-” Nakshatra of germs containing bacteria that live under normal conditions in our intestine “-There is a possible criminal of collaborate colorectal cancer.
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“It is now less surprising than a decade ago that any form of bacteria – more especially, a toxin obtained from bacteria – possibly can be the primary cause of cancer,” Lu, who was not involved in the study, told Fox News Digital.
“What is particularly related to is the long period of time that may miss the early bacteria in life, and the time is diagnosed before the related cancer.”
Potential limits
Alexandrov reported that the study provides a “strong genomic evidence” of a “striking association” between colibactin and early colorectal cancer, but it could not prove.
He said, “Displaying inequality – proving that colibactin alone is sufficient to start cancer in humans alone – a significant challenge,” he told Fox News Digital.
Colorectal cancer cases have doubled in adults under 50 for each of the last two decades, showing statistics. (Istock)
“Fixed evidence of work-causing will require long-term possible studies starting in childhood to track microbial colonization and cancer in several decades.”
Lu agreed with this limit, taking into account the complexity of cancer factors.
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“There are many aspects of our environment – both inside and outside our body – who can play a role in the development of cancer,” he said. “It is difficult to say or conclude whether there is a single factor-in this case, bacteria-rituals are correct or even a major cause of venom-colorectal cancer.”
“Providing evidence of a potential association determines the foundation for more depth study to determine what is the correct cause and effect,” Lu said.
“If the current trends continue, colorectal cancer is expected to become a major cause of cancer related death in young adults by 2030.”
Alexandrov said that while findings do not yet change screening or treatment guidelines, they highlight “an important role of microbial exposure of early life” in terms of the risk of long -term cancer.
“We are actively working when we are actively working on developing a screening tests to detect the long -term effects of the collabactin exposure, with the goal of translating these conclusions into practical prevention strategies in the near future,” he said.
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Colorectal cancer cases have doubled in adults under 50 for each of the last two decades, showing statistics.
“If the current trends continue, colorectal cancer is estimated to be a major cause of cancer -related death in young adults by 2030,” researchers concluded.
