The human brain suddenly starts aging very fast around the age of 44 years, and the aging reaches the maximum speed at the age of 67, finds a new study.
Research published on March 3 in the journal ownerTo align with the results of a separate study, it seems that Live Sciences recently reported, which saw the aging using blood samples and found that Quick aging duration is around 44 and 60 years of age,
The new neuroscience study also found that the brain was associated with aging. insulin resistanceIn which cells require more insulin than normal to keep blood sugar. In addition, it highlighted early signs that ketone dose may provide some protection against some measures of brain aging.
Ketones There are compounds in the body that act as an alternative fuel source, which stand for sugars. So if the brain is for aging because it is not getting enough sugars, then ketones can help fill the difference, the team gave the principle.
However, much more research is required to return this idea.
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Initial warning indication of brain aging
Researchers used four existing datasets of brain scans, which included scans from 19,300 people between the ages of 18 and 90 together. To study how separate areas are added to the network, the team saw two types of brain scans: functional magnetic resonance imaging (FMRI), which measures blood flow to the brain, and electrical firing between electrical firing (EEGS), which measures electrical firing.
In these scans, scientists searched for indications that blood flow and electric firing between the brain areas either disappeared or disappeared, suggesting that a breakdown in communication between the nodes in the network was detected. He considered this network disintegration as an identity of aging previous research In which he assessed the effect of diet on the brain. Such disruptions are also seen in age -related neurodynative diseases, and the degree of disruption usually reflects the overall degree of aging of the person.
Through their analysis, researchers found that the brain begins to age more quickly around 44 years of age and the age of aging increases to the maximum rate of 67 years. After that, the brain starts aging, until the rate becomes stable around the age of 90 years.
While studying a senior writer, Lillian Mujika-CoriA neuroscientist at Stony Brook University told Live Science.
Sugar vs. Keton
The network disintegration by the researchers is similar to changes Earlier document In the minds of people between the ages of 50 to 80 years Type 2 diabetesMujika-Podi and her team wondered whether changes arose because neurons were not responding well to insulin, hormones responsible for closing sugar in cells from blood.
This effect will not only affect people with diabetes. “88% of North Americans are at least one of the detectable indications of insulin resistance,” Dr. Luis Adrian Soto-MetaA metabolic researcher who was not involved in the study at the Monteri Institute of Technology in Mexico, but first worked with the team.
Given all brain scans, which included scans with insulin resistance and without people, the team found that in the 40s people are with high Bloody Levels experienced rapid brain aging compared to people of the same age, with no signs of insulin resistance.
In addition, in all scans, in parts of the brain grew faster than others, so researchers thought whether those brain areas could depend on more insulin. It is known that the name of a protein Glut4 depends on insulin To take sugar into cells. So turned to the team Allen brain atlasWhich includes data on the activity of the Glut4 gene, and found that fast-aging areas depended more on GLUT4.
On the other hand, in slow -growing brain areas, there was a high level of protein that carries ketones into cells, suggests that they use ketones as an alternative energy source.
Connected: We could not be inspired by what we thought of biological aging
Ketone supplements?
The question raised whether ketone dose might be able to slow down brain aging. To test the idea, the team recruited 53 men and 48 women, who were 20 to 79, who got an FMRI scan after fasting overnight to deprive the brain of Chinese.
Half an hour after the scan, the participants found either a drink full of ketone or a sugary drink with the same number of calories. Researchers waited 30 minutes for the energy source to reach the minds of the participants before repeating the FMRI scan.
Even on this short time, the ketone drink appeared to reduce the disruption of the brain network tied to aging, while the team found not glucose drinks.
Ketone drinks had the greatest effect on people between the ages of 40 and 59, where its effect was more than 80% of young adults between the ages of 20 to 39 years. Ketone drinks had the smallest effect in the 60 to 79 age group. This may indicate that, if the dose of ketone proves effective to slow the aging of the brain, initial intervention may be necessary.
This part of the study was limited by the fact that researchers tested the effects of ketones and glucose drinks at only one time point; They did not monitor the aging of the brain over time or conducted any cognitive testing. He also considered only specific FMRI data, which cannot reflect all aspects of brain aging, so we do not know whether the dose of ketone would help in the board.
The Mujika-Cardidi said that future studies can track the aging of the brain in people taking these supplements over time and thus provide greater insight into its long-term capacity. In addition, if the dose of ketone is made for insulin resistance, then the best remedies that can be taken to avoid developing insulin resistance at first, they suggested, which can be obtained through which can be obtained through Dietary change,
Soto-Meta said that when the glucose level is quite low, the body can make more ketones by itself, which can be achieved by supplementation. This is the goal of “keto diet”, although maintaining diet for a long time Comes with downsides,
Mujika-Pawodi said that ketone supplements can be helpful in people with extreme insulin resistance who are unable to make their own ketones due to metabolic changes in the body.
Note the editor: Some authors of the new paper have patented the ketone supplement tested in the research, and the director of a company is aimed at developing the science -based products based on keton bodies in human nutrition.
This article is only for informative purposes and does not mean to give medical advice.
