According to disease control and prevention centers, flu vaccine is recommended for all Americans for all Americans – but a new study of Cleveland Clinic shows that it may not have those protective effects that people expect.
Preprint study, which was published on Medrxiv.org this week, saw the data of infection for the 2024–2025 flu season.
Researchers found that obtaining influenza vaccine in North Ohio was associated with 27% increase in flu infections.
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Commentary employees were compared to those who did not get the vaccine over a period of 25 weeks.
According to the disease control and prevention centers, flu vaccine is recommended for 6 months and older of all Americans. (Joe Redal/Getty Images)
Researchers wrote in the study, “The study found that the vaccination of the working-aZ adults influenza was associated with a high risk of influenza during the 2024-2025 respiratory viral season, suggesting that the vaccine has not been effective in preventing influenza in this season.”
While the previous work has been published in major magazines by these researchers on vaccine effectiveness, the most recent study is still in the pre-print phase, meaning that it has not yet been reviewed by colleagues.
Potential limits
Researchers referred to several limitations of study, including “Trevant inactive influenza vaccine” was used in about 99% of employees involved.
“The possibility that other influenza vaccines may be more effective, they cannot be excluded,” he wrote.
It is also possible that the home testing kits may have missed some infections.

Researchers wrote in the study, “The study found that the vaccination of the working-aZ adults influenza was associated with a high risk of influenza during the 2024-2025 respiratory viral season, suggesting that the vaccine has not been effective in preventing influenza in this season.” (Istock)
Additionally, the study did not compare the risk of flu -related hospitals or the risk of deaths, nor measure whether the vaccine had reduced the severity of the disease.
Researchers wrote, “Our study of healthcare personnel did not include no children and some elderly subjects, and was mainly involved in individuals who were healthy enough to be employed,” the researchers wrote. “A minority was expected to be severely immunized.”
Doctor weighs
Dr. Dr. Dr. Dr. Dr. Langon Health and Fox News Clinical Professor Dr. Mark Sigal reviewed the findings of the study and said the results are “misleading.”
“This is observation, so it does not prove that the vaccine does not spread,” he told Fox News Digital.
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“The biggest bias that I am seeing is that it is comparing vaccinated healthcare workers (80% vaccinated against flu) with general population trends, as the study does not keep in mind that healthcare laborers are more likely to come in contact with flu in their profession, so we will expect to expect more, whether the infection darling or not.”
Seagal also said that he believes that the study misuses the word “effectiveness”.

The study did not compare the risk of flu -related hospitals or deaths in the flu, nor did it measure whether the vaccine had reduced the severity of the disease. (Istock)
“Flu vaccine aims to reduce severity rather than spread,” he said.
“Flu vaccine effectiveness has a real yardstick hospitalization or a doctor’s office or immediate care rate, usually below the vaccine for more than 100,000 or more due to the vaccine.”
“Flu vaccine aims to reduce severity rather than spreading.”
The doctor said that this effectiveness is different, how well the vaccine is.
“At the same time, the flu vaccine reduces the viral load, which must reduce the spread of overalls within a community.”
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San Francisco Biotechnology Company, CEO of Sentivax, Dr. Jacob Glenville echoed that the study had not yet reviewed the colleague.
“We must wait for that process, as it will work to examine statistical methods and other study design ideas,” he told Fox News Digital.

A doctor said, “I still tell my patients that the benefit of getting a flu vaccine is that even though you can get the flu, your case cannot be as serious as the flu vaccine does not.” (Istock)
“For example, it would be important to mention this to avoid reporting by employees of non-vicious Cleveland Clinic. Do they have any policies that discourage non-proclaimed subjects to report the disease?”
“The whole world is affected by influenza, so if this phenomenon is real, it should be easily supported by other studies of this season.”
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A family doctor located in Salem, Ohio, Dr. Mike Sevila agreed that the high rate of infection suggests that this year’s influenza vaccine was not as effective as expected.
“I don’t think this is expected. However, compared to previous years, the effectiveness of the annual flu vaccine may vary widely, from about 10% to about 60%,” he said in an interview with Fox News Digital.
“The effectiveness of the annual flu vaccine can vary widely, from about 10% to about 60%.”
Sevila shared that in his office, he saw an increase in influenza cases this season, but not necessarily serious cases.
“I still tell my patients that the advantage of getting a flu vaccine is that even if you can get a flu, your case cannot be as serious as the flu vaccine was not received,” he said.
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“If you have any questions about the vaccine, you can always ask your family doctor.”
Fox News reached the Cleveland Clinic researchers for digital comments.