Experimental antifungal compound kills multidrug-resistant fungi

The discovery of a new pregnant compound with strong antifungal activity against multidrig-resistant pathogens It has been told In NatureThe drug, antifungal properties, is a member of a known family of bacteria products with a drug, antifungal properties, a drug, antifungal properties. Unlike known compounds in this family, the mandimicin fungal cell connects a novel in the membrane and is therefore active against a series of pathogens that are resistant to the respective compounds.

Infection caused by multidrig-resistant fungi pathogens pose a serious threat to human health, requiring an alternative treatment. Bacteria have developed to produce natural products that can kill fungi, and these products have been used to develop antifungal drugs for humans.

However, the resistance is widespread and traditional antifungal drug discovery strategies (for example, testing the activity of natural products found in environmental samples) are decreasing anytime, as they often lead to the redistribution of compounds that connect to the known goals.

To identify new members of the polyin macrolide family with the ability to bind for alternative goals, Zongkiang Wang and colleagues examined 316,123 bacterial genomes to identify novel gene groups. One such cluster developed separately from other gene groups that encoded polyin macrolides.

Subsequent experiments showed that its product does not connect with argosterol in the cell membrane, which is the specific goal of polyin macrolyides. Instead, the mandimicin was shown to tie various phospholipids into the fungal cell membrane. This mode of action means that this fungus is effective against pathogens who have developed resistance to existing antifungal agents that target ergosterol, such as clinically used agents Emphocin B.

The authors used the animal model of infection to test the mandimicin against a series of fungal pathogens, including multidrig-resistant Candida Oris (a species listed as a danger of fungi-priority fungi), and found that the compound had increased the efficacy and found the ecstroxicity, as the ecstrosicism was reduced, as the ecstrosicism was reduced. Was compared in.