Giving blood linked to lower risk of pre-cancer gene

People who give blood regularly have more chances of genetic changes in their blood that can reduce the risk of cancer development, showing a study.

Researchers at the Francis Crick Institute say the conclusions are “attractive” and can help understand how and why blood cancer develop.

His study compared blood of two groups of healthy male donors in the 60s – the first gave blood three times a year for 40 years, the second only five times the total.

Micro -genetic differences were not associated with high risk of blood cancer, often -present in more of the groups -but because healthy people do to give blood, it slant the picture.

With age, cells in the body – including blood – naturally develop mutations, which increases the risk of diseases such as cancer development.

When people donate blood, stem cells in the bone marrow form new blood cells to replace lost blood – and it can shape the genetic variety of stem cells.

Researchers found a similar level of natural genetic mutations in the blood of two groups – 217 consecutive and 212 irregular donors.

But the type of mutation in stem cells was subtle formally:

• 50% of consistent donors
• 30% of irregular donors

Analyzed in the laboratory, this mutation increased in different environment in a different way, which is associated with other mutations associated with diseases such as leukemia, a type of blood cancer.

“This is a type of mutation that is not associated with the high risk of leukemia development,” the author of the study, Dr. Hector Huigarga Enkabo said.

And when mice were injected with these human blood stem cells in the lab, the cells were found to be good in making red blood cells – a positive sign, Dr. Ankabo said.

Research published in Journal Blood was organized with scientists in Heidelberg and with the help of the German Red Cross Blood Donation Center.

But the results do not prove that donating blood reduces the chances of development of initial blood cancer.

Senior writer Dominic Bonton, who is head of a stem-cell laboratory in the crick, said, “It may be that those who donate blood are more likely to be healthy if they are eligible and also reflected in their blood-cell clone,” senior writer dominic bonnet, which leads a stem-cell laboratory in the cricch, said.

And the research team is now planning to analyze blood of a large number of people, including women.

Current conclusions are a reminder that are everyday small things – how the environment of the people changes – as well as their age, their tissues and blood, changing the stem cells, said Dr. Inko.

NHS Blood and Transplant said the research was “interesting”, but further work was needed, as healthy people were more likely to donate.

Medical Director Dr. “Healthy-Danner Effects’ usually makes the donor health difficult to study,” Lisay Estcort said.

“However, the most important thing is that people chose to donate to improve the health of others.”

The current stocks were “severely low”, the organization said.

In the UK, fit and healthy 17-65-year children can give blood-they meet all other criteria-but not if they have cancer, then an organ has been tested positively for human immunodeficiency virus (HIV) due to transplantation or other reasons.

And some people may have to wait, for example, if they have a child in the last six months or recently a tattoo or piercing.